LUMIER MEDICAL

Dermal Fillers

Everyone will notice, but no one will know.

Restore or enhance the younger you!

Many people are worried that fillers will make them look puffy or unnatural looking.  Visit our gallery section to see how fillers can enhance ones youthful appearance without looking overdone.  We can now restore volume to hollow temples, cheeks, lips, jawline, and the chin area.  We can also treat the lines of the neck and restore volume to aged hands. 

What are fillers?

Hyaluronic acid fillers are reversible transparent gels that add volume when injected into soft tissue.  They are often referred to as “dermal fillers,” because years ago they were mostly injected into the dermis, the thick part of the skin. 

Filler injections are sought after by adults of all ages.  The most popular fillers are made of a sugar substance called Hyaluronic Acid, abbreviated simply as “HA.”  They are injected into or under the skin to help fill in wrinkles, provide volume to soft tissues, and balance out facial features. 

HA filler injections are the second most popular nonsurgical cosmetic procedures performed in the United States. BOTOX Cosmetic and BOTOX-like toxins are the most commonly sought after nonsurgical cosmetic procedures.  Fillers and Botox are often used in combination to achieve the best results.

We now have over 20 different types of hyaluronic acid fillers that are FDA-approved.  These include 8 types of Restylane, 7 types of Juvederm, Belotero Balance+, Revanesse Versa+, Revanesse Lips+, RHA Redensity, RHA 2, RHA 3, and RHA 4.   See the Fillers Comparison Table toward the bottom of this page.

The variety of fillers we now have allows the injector to choose “the right tool for the job.” 

What happens if I stop using fillers?

It is a myth that fillers will make you look worse once you stop using them. Think about how shoe trees help your shoes keep their shape and avoid creasing of the leather.

Let’s face it. We are deflating with age. Fillers help delay signs of aging.

What happened to collagen fillers?

Zyderm and Zyplast were bovine collagen fillers that were popular, starting in the 1980s.  Unlike bovine collagen filler that was made of a protein derived from a cow, hyaluronic acid is a non-animal product.

Hyaluronic acid (HA) is a naturally occurring sugar substance that your body produces.  Most of your body’s hyaluronic acid is in your skin.  It can also be found in your joints, your eyes, and in other parts of your body.

HA fillers last much longer than collagen, require no skin testing prior to treatment, and are reversible.  In 2003, Restylane, the first FDA-approved HA filler in the United States became the new benchmark by which others followed.

HA fillers are modified and stabilized during the manufacturing process to give them longevity and special physical characteristics for cosmetic use.

A filler comparison table is included below.

  • Creases, wrinkles, and folds may be just the tip of the iceberg. As we age, our face deflates. The layers of skin, fat, muscle, and even bone lose volume. Would you rub moisturizer onto a wrinkled helium balloon or fill it back up with helium?

    Fillers can be injected into soft-tissue using a needle or smooth-tipped cannula using a variety of different techniques. Frequent areas of treatment include the temples, outer cheeks, inner cheeks, nasolabial folds (aka NLF or “smile lines”), lips, and lines around the lips, marionette lines, chin area, jawline, the back of hands, and other off-label areas.

  • A conscientious provider will continually expand his or her fund of knowledge. Your injector must have a thorough understanding of 3-Dimensional facial anatomy, high-risk treatment zones, potential filler-related complications, and know how to minimize risks and treat complications. Make an educated decision about who you choose to perform your procedure(s). You should prioritize provider experience, knowledge, and one who has a track record of good outcomes.

  • Products vary in price and can range from $410 to $833/syringe.

    The aging process is continual and due to many different causes. Years of volume loss contribute to this by the time most individuals seek treatment. There is rarely a one-and-done procedure. Full correction may take multiple syringes or a combination of treatments over time. This is why it is best to consult with your provider face-to-face, so that a proper evaluation can be done. You and your provider will explore treatment options depending on your needs, expectations, and budget.

    Legitimate practices know the cost of FDA-approved products. When offices offer HA fillers near wholesale cost, this raises a red flag. Providers are often approached by unauthorized suppliers of HA fillers that have not been approved by the FDA for use and sale in the United States. It is illegal for individuals to import drugs or devices into the U.S. from other countries in most circumstances. Legal issues aside, are these products vetted to be safe? Are they counterfeit products?

    Once you find a credible provider, pay for the honest expert injector, not just for the product. A good injector will always be focused in providing you the best outcomes, with a huge emphasis on safety!

  • The 4 Rs of facial rejuvenation use a comprehensive approach to address different aspects of aging:

    • Relax – Botulinum Toxin A (5 different FDA-approved types) is used to relax muscles of expression and to soften the creasing of skin. Over time, untreated creases get deeper.

    • Refill – HA fillers, biostimulators, fat (autologous or exogenously sourced). Over time, we are deflating. Biostimulators include Sculptra, Radiesse, and Bellafill.

    • Resurface – procedures that restore youthful skin surface qualities (superficial volume, even color, texture, tone, tightness). This category may include chemical peels, laser and light modalities, microneedling with or without radio frequency (RF), other energy modalities, platelet-rich plasma (PRP) in combination with some of the above, prescriptive and/or cosmeceutical products, PDO threads.

    • Redrape – this category surgically addresses loose skin (e.g., eyelid lift, face lift, neck lift).

For more details,

read on…

Product**HA [ ]
mg/ml
Proprietary
Stabilization
Boxed
Needle
Injection DepthCharacteristics,
Molecular Weight (LMW vs HMW) 1
Worth
Mentioning
Lips?
(FDA)
Dynamic Strength Score (Pa2) 14Stretch
Score 14
G’ 14
(Pa)
(%) Degree of Modification (MoD)*
Restylane-L20NASHA
Biphasic, BDDE
29GMid-to-deep dermisUniform Particle Size
HMW HA.
Medium-sized Particle
350-450 µm
YES3270015.47921.10%
Restylane
LYFT
20NASHA
Biphasic, BDDE
29GSubcutaneous and/or supraperiostealUniform Particle Size
HMW HA.
[Robust]
Large-sized
Particle
750-1000 µm.
NLF, midface, hands
350008.58071.20%
Restylane
SILK
20NASHA
Biphasic, BDDE
30GMid-to-deep dermisUniform Particle Size
HMW HA.
(lots of swelling)
Small sized Particle
50-200 µm
YES1%
Restylane
REFYNE
20xPresHAn30GMid-to-deep dermisVery elastic
HMW HA.
Among xPresHAn, most flexible and least supportive4140186.773.55.70%
Restylane
KYSSE
20xPresHAn30GLip mucosaVery elastic, more supportive than Refyne
HMW HA.
FDA approved for lips onlyYES
Restylane
DEFYNE
20xPresHAn27GMid-to-deep dermisLess elastic, but more supportive than Kysse
HMW HA.
4080025.9220.78.40%
Restylane
CONTOUR
20xPresHAn27GSubcutaneous and/or supraperiostealVery Supportive
HMW HA.
[Robust]
For midface72
Juvederm
ULTRA XC
24Hylacross
Monophasic
Monodensified
BDDE
30GMid-to-deep dermisHMW HA.Slightly thinner and less hydrophilic than Ultra PlusYES11100134.4102.15.90%
Juvederm
ULTRA PLUS XC
24Hylacross
Monophasic
Monodensified
BDDE
27GMid-to-deep dermisHMW HA.Slightly thicker and more hydrophilic than Ultra2430091.8136.66.90%
Juvederm VOLBELLA XC15Vycross
Monophasic
Monodensified
BDDE
32GLip mucosaMostly LMH HA.Among Vycross, least supportiveYES878043.1219.55.30%
Juvederm VOLURE XC17.5Vycross
Monophasic
Monodensified
BDDE
30GMid-to-deep dermisMostly LMW HA.Among Vycross,
Medium to low support
1830033.4274.65.60%
Juvederm VOLUMA XC20Vycross
Monophasic
Monodensified
BDDE
27GDeep
subcutaneous
and/or
supraperiosteal
Mostly LMW.
[Robust]
Among Vycross,
Very Supportive
For midface and chin
3340020.1305.45.90%
Juvederm VOLUX XC25Vycross
Monophasic
Monodensified
BDDE
27GSubcutaneous and/or supraperiostealMostly LMW.
[Very Robust]
Among Vycross,
Most lifting

For jawline
665 21
Belotero
BALANCE+
22.5CPM
Monophasic
Polydensified
BDDE
30GMid-to-deep dermisHMW HA.
Integrates into skin easily. Very low Dynamic Strength Score (Pa2). Most “squishable.” 22
Very forgiving for superficial creases. Does not last long.128 21
Revanese VERSA+25Thixofix
Monophasic
BDDE
27GMid-to-deep dermisSpherical Particles, less hydrophilic
HMW HA.
Revanesse
LIPS+
25Thixofix
Monophasic
BDDE
30GLip mucosaSpherical Particles, less hydrophilic.
HMW HA.
Same product as Versa. Different packaging, smaller needle.YES
RHA REDENSITY
(Teoxane)
15Preserved
Network
Low degree of BDDE
30GSuperficial-to-mid dermisHMW HA.Most stretchable of all the HA products4390792133 211.90%
RHA 2 (Teoxane)23Preserved
Network
Low degree of BDDE
30GMid-to-deep dermis
May use for radial cheek lines.
HMW HA.RHA stands for Resilient Hyaluronic
Acid
22000227138.93.10%
RHA 3 (Teoxane)23Preserved
Network
Low degree of BDDE
27GMid-to-deep dermisHMW HA.3190085.3145.83.60%
RHA 4
(Teoxane)
23Preserved
Network
Low degree of BDDE
27GDeep dermis and/or superficial subcutaneousHMW HA.
[Most Robust of RHA line]
8190055263.34%

** Restylane products (Galderma), Juvederm Products (Abbvie(Allergan)), Belotero Balance (Merz Aesthetics), Revanesse Products (Prollenium Medical Technologies), RHA (Revance Aesthetics).
RHA PRESERVED NETWORK Technology that uses a lower degree of modification/crosslinking.  Designed to preserve long HA chains from fragmentation in the manufacturing process.  

LEGEND

  • Hyaluronic Acid (HA) A water soluble sugar polymer that belongs to a class of compounds known as glycosaminoglycans.  It is made up of long chains of repeating disaccharide units of N-acetylglucosamine and glucuronic acid.18

  • HA Chain Length ∝ Molecular Weight HA chain length is associated with (proportional to) the molecular weight of the HA chain.18 Short HA Chains = Low Molecular Weight (LMW), Long HA Chains = High Molecular Weight (HMW).

  • Monophasic Cross-links formed between hyaluronic acid chains make a uniform gel-like structure.

  • Biphasic Biphasic material consists of 2 or more substances in a blend.  In the case of hyaluronic acid, it can exist in two different physical states:  cross-linked HA and non-cross-linked HA. Biphasic material is not homogenous (not uniform in character or content).

  • (%) Degree of Modification (MoD) Degree of Modification (MoD) is the ratio of chemical crosslinkers that form cross-links to the total number of HA disaccharide units.

  • Dynamic Strength Score (Pa2) The Dynamic Strength Score characterizes the ability of a gel to maintain its physical integrity and gel characteristics over a wide range of stress or deformation values15

  • Stretch Score (%/s) Stretch is the ability of the gel to deform (e.g., extend) and adapt to dynamic facial movement.  The Stretch Score describes the ability of an HA gel to deform without disruption when subjected to continuous pressure.

  • G’ (Pa) Elastic modulus or storage module (G’) describes the ability of a gel to rebound to its original shape when a force is applied.  High G’ usually correlates with a firmer gel. 16                 

    • 1  Micheels P et al. J Drug Dematol. 2016;15(5):600-606.

    • 14 Data on File. RDRE 2016. Newark, CA: Revance Therapeutics, Inc, 2020.

    • 15 Faivre J et al. Poster presented at: 2020 IMCAS; January, 2020; Paris, France.

    • 16 Fagien S et al. Plast Reconstr Surg. 2019;143:707e-720e.

    • 18 Monslow J et al. Front Immunol. 2015;6:231.

    • 21 Rheologic and Physicochemical Characteristics of HA Fillers: Overview and Relationship to Product Performance, Facial Plast Surg 2022;38:116–123.  It is notable that published G’ values differ depending on the study and information source.

    • 22 “Squishable” as an anecdotal observation by Dr. Lum and other injectors when product is injected superficially.

  • American Society of Plastic Surgeons.  2018 plastic surgery statistics report, published 2019.

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