LUMIER MEDICAL

Fillers Comparison

With so many fillers to choose from, ask us for details.

We now have over 20 different types of fillers approved by the United States Food and Drug Administration (FDA).
There is no one-size-fits-all product.

Fillers:

  • RESTYLANE-L

    RESTYLANE-LYFT

    RESTYLANE SILK

    RESTYLANE REFYNE

    RESTYLANE KYSSE

    RESTYLANE DEFYNE

    RESTYLANE CONTOUR

    RESTYLANE EYELIGHT

  • JUVÉDERM ULTRA XC

    JUVÉDERM ULTRA PLUS XC

    JUVÉDERM VOLBELLA XC

    JUVÉDERM VOLLURE XC

    JUVÉDERM VOLLUMA XC

    JUVÉDERM VOLLUX

    JUVÉDERM SKINVIVE

  • BELOTERO BALANCE

  • REVANESSE VERSA™+

    REVANESSE LIPS™+

  • RHA REDENSITY

    RHA 2

    RHA 3

    RHA 4

Want details?

Here goes…

Product**HA [ ]
mg/ml
Proprietary
Stabilization
Boxed
Needle
Injection DepthCharacteristics,
Molecular Weight (LMW vs HMW) 1
Worth
Mentioning
Lips?
(FDA)
Dynamic Strength Score (Pa2) 14Stretch
Score 14
G’ 14
(Pa)
(%) Degree of Modification (MoD)*
Restylane-L20NASHA
Biphasic, BDDE
29GMid-to-deep dermisUniform Particle Size
HMW HA.
Medium-sized Particle
350-450 µm
YES3270015.47921.10%
Restylane
LYFT
20NASHA
Biphasic, BDDE
29GSubcutaneous and/or supraperiostealUniform Particle Size
HMW HA.
[Robust]
Large-sized
Particle
750-1000 µm.
NLF, midface, hands
350008.58071.20%
Restylane
SILK
20NASHA
Biphasic, BDDE
30GMid-to-deep dermisUniform Particle Size
HMW HA.
(lots of swelling)
Small sized Particle
50-200 µm
YES1%
Restylane
REFYNE
20xPresHAn30GMid-to-deep dermisVery elastic
HMW HA.
Among xPresHAn, most flexible and least supportive4140186.773.55.70%
Restylane
KYSSE
20xPresHAn30GLip mucosaVery elastic, more supportive than Refyne
HMW HA.
FDA approved for lips onlyYES
Restylane
DEFYNE
20xPresHAn27GMid-to-deep dermisLess elastic, but more supportive than Kysse
HMW HA.
4080025.9220.78.40%
Restylane
CONTOUR
20xPresHAn27GSubcutaneous and/or supraperiostealVery Supportive
HMW HA.
[Robust]
For midface72
Juvederm
ULTRA XC
24Hylacross
Monophasic
Monodensified
BDDE
30GMid-to-deep dermisHMW HA.Slightly thinner and less hydrophilic than Ultra PlusYES11100134.4102.15.90%
Juvederm
ULTRA PLUS XC
24Hylacross
Monophasic
Monodensified
BDDE
27GMid-to-deep dermisHMW HA.Slightly thicker and more hydrophilic than Ultra2430091.8136.66.90%
Juvederm VOLBELLA XC15Vycross
Monophasic
Monodensified
BDDE
32GLip mucosaMostly LMH HA.Among Vycross, least supportiveYES878043.1219.55.30%
Juvederm VOLURE XC17.5Vycross
Monophasic
Monodensified
BDDE
30GMid-to-deep dermisMostly LMW HA.Among Vycross,
Medium to low support
1830033.4274.65.60%
Juvederm VOLUMA XC20Vycross
Monophasic
Monodensified
BDDE
27GDeep
subcutaneous
and/or
supraperiosteal
Mostly LMW.
[Robust]
Among Vycross,
Very Supportive
For midface and chin
3340020.1305.45.90%
Juvederm VOLUX XC25Vycross
Monophasic
Monodensified
BDDE
27GSubcutaneous and/or supraperiostealMostly LMW.
[Very Robust]
Among Vycross,
Most lifting

For jawline
665 21
Belotero
BALANCE+
22.5CPM
Monophasic
Polydensified
BDDE
30GMid-to-deep dermisHMW HA.
Integrates into skin easily. Very low Dynamic Strength Score (Pa2). Most “squishable.” 22
Very forgiving for superficial creases. Does not last long.128 21
Revanese VERSA+25Thixofix
Monophasic
BDDE
27GMid-to-deep dermisSpherical Particles, less hydrophilic
HMW HA.
Revanesse
LIPS+
25Thixofix
Monophasic
BDDE
30GLip mucosaSpherical Particles, less hydrophilic.
HMW HA.
Same product as Versa. Different packaging, smaller needle.YES
RHA REDENSITY
(Teoxane)
15Preserved
Network
Low degree of BDDE
30GSuperficial-to-mid dermisHMW HA.Most stretchable of all the HA products4390792133 211.90%
RHA 2 (Teoxane)23Preserved
Network
Low degree of BDDE
30GMid-to-deep dermis
May use for radial cheek lines.
HMW HA.RHA stands for Resilient Hyaluronic
Acid
22000227138.93.10%
RHA 3 (Teoxane)23Preserved
Network
Low degree of BDDE
27GMid-to-deep dermisHMW HA.3190085.3145.83.60%
RHA 4
(Teoxane)
23Preserved
Network
Low degree of BDDE
27GDeep dermis and/or superficial subcutaneousHMW HA.
[Most Robust of RHA line]
8190055263.34%

LEGEND

  • Hyaluronic Acid (HA) A water soluble sugar polymer that belongs to a class of compounds known as glycosaminoglycans.  It is made up of long chains of repeating disaccharide units of N-acetylglucosamine and glucuronic acid.18

  • HA Chain Length ∝ Molecular Weight HA chain length is associated with (proportional to) the molecular weight of the HA chain.18 Short HA Chains = Low Molecular Weight (LMW), Long HA Chains = High Molecular Weight (HMW).

  • Monophasic Cross-links formed between hyaluronic acid chains make a uniform gel-like structure.

  • Biphasic Biphasic material consists of 2 or more substances in a blend.  In the case of hyaluronic acid, it can exist in two different physical states:  cross-linked HA and non-cross-linked HA. Biphasic material is not homogenous (not uniform in character or content).

  • (%) Degree of Modification (MoD) Degree of Modification (MoD) is the ratio of chemical crosslinkers that form cross-links to the total number of HA disaccharide units.

  • Dynamic Strength Score (Pa2) The Dynamic Strength Score characterizes the ability of a gel to maintain its physical integrity and gel characteristics over a wide range of stress or deformation values.15

  • Stretch Score (%/s) Stretch is the ability of the gel to deform (e.g., extend) and adapt to dynamic facial movement.  The Stretch Score describes the ability of an HA gel to deform without disruption when subjected to continuous pressure.

  • G’ (Pa) Elastic modulus or storage module (G’) describes the ability of a gel to rebound to its original shape when a force is applied.  High G’ usually correlates with a firmer gel.16                 

    • 1  Micheels P et al. J Drug Dematol. 2016;15(5):600-606.

    • 14 Data on File. RDRE 2016. Newark, CA: Revance Therapeutics, Inc, 2020.

    • 15 Faivre J et al. Poster presented at: 2020 IMCAS; January, 2020; Paris, France.

    • 16 Fagien S et al. Plast Reconstr Surg. 2019;143:707e-720e.

    • 18 Monslow J et al. Front Immunol. 2015;6:231.

    • 21 Rheologic and Physicochemical Characteristics of HA Fillers: Overview and Relationship to Product Performance, Facial Plast Surg 2022;38:116–123.  It is notable that published G’ values differ depending on the study and information source.

    • 22 “Squishable” as an anecdotal observation by Dr. Lum and other injectors when product is injected superficially.

  • American Society of Plastic Surgeons.  2018 plastic surgery statistics report, published 2019.

Previous
Previous

Dermal Fillers

Next
Next

Biostimulators