LUMIER MEDICAL
Fillers Comparison
With so many fillers to choose from, ask us for details.
We now have over 20 different types of fillers approved by the United States Food and Drug Administration (FDA).
There is no one-size-fits-all product.
Fillers:
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RESTYLANE-L
RESTYLANE-LYFT
RESTYLANE SILK
RESTYLANE REFYNE
RESTYLANE KYSSE
RESTYLANE DEFYNE
RESTYLANE CONTOUR
RESTYLANE EYELIGHT
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JUVÉDERM ULTRA XC
JUVÉDERM ULTRA PLUS XC
JUVÉDERM VOLBELLA XC
JUVÉDERM VOLLURE XC
JUVÉDERM VOLLUMA XC
JUVÉDERM VOLLUX
JUVÉDERM SKINVIVE
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BELOTERO BALANCE
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REVANESSE VERSA™+
REVANESSE LIPS™+
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RHA REDENSITY
RHA 2
RHA 3
RHA 4
Want details?
Here goes…
| Product** | HA [ ] mg/ml | Proprietary Stabilization | Boxed Needle | Injection Depth | Characteristics, Molecular Weight (LMW vs HMW) 1 | Worth Mentioning | Lips? (FDA) | Dynamic Strength Score (Pa2) 14 | Stretch Score 14 | G’ 14 (Pa) | (%) Degree of Modification (MoD)* |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Restylane-L | 20 | NASHA Biphasic, BDDE | 29G | Mid-to-deep dermis | Uniform Particle Size HMW HA. | Medium-sized Particle 350-450 µm | YES | 32700 | 15.4 | 792 | 1.10% |
| Restylane LYFT | 20 | NASHA Biphasic, BDDE | 29G | Subcutaneous and/or supraperiosteal | Uniform Particle Size HMW HA. [Robust] | Large-sized Particle 750-1000 µm. NLF, midface, hands | 35000 | 8.5 | 807 | 1.20% | |
| Restylane SILK | 20 | NASHA Biphasic, BDDE | 30G | Mid-to-deep dermis | Uniform Particle Size HMW HA. (lots of swelling) | Small sized Particle 50-200 µm | YES | 1% | |||
| Restylane REFYNE | 20 | xPresHAn | 30G | Mid-to-deep dermis | Very elastic HMW HA. | Among xPresHAn, most flexible and least supportive | 4140 | 186.7 | 73.5 | 5.70% | |
| Restylane KYSSE | 20 | xPresHAn | 30G | Lip mucosa | Very elastic, more supportive than Refyne HMW HA. | FDA approved for lips only | YES | ||||
| Restylane DEFYNE | 20 | xPresHAn | 27G | Mid-to-deep dermis | Less elastic, but more supportive than Kysse HMW HA. | 40800 | 25.9 | 220.7 | 8.40% | ||
| Restylane CONTOUR | 20 | xPresHAn | 27G | Subcutaneous and/or supraperiosteal | Very Supportive HMW HA. [Robust] | For midface | 72 | ||||
| Juvederm ULTRA XC | 24 | Hylacross Monophasic Monodensified BDDE | 30G | Mid-to-deep dermis | HMW HA. | Slightly thinner and less hydrophilic than Ultra Plus | YES | 11100 | 134.4 | 102.1 | 5.90% |
| Juvederm ULTRA PLUS XC | 24 | Hylacross Monophasic Monodensified BDDE | 27G | Mid-to-deep dermis | HMW HA. | Slightly thicker and more hydrophilic than Ultra | 24300 | 91.8 | 136.6 | 6.90% | |
| Juvederm VOLBELLA XC | 15 | Vycross Monophasic Monodensified BDDE | 32G | Lip mucosa | Mostly LMH HA. | Among Vycross, least supportive | YES | 8780 | 43.1 | 219.5 | 5.30% |
| Juvederm VOLURE XC | 17.5 | Vycross Monophasic Monodensified BDDE | 30G | Mid-to-deep dermis | Mostly LMW HA. | Among Vycross, Medium to low support | 18300 | 33.4 | 274.6 | 5.60% | |
| Juvederm VOLUMA XC | 20 | Vycross Monophasic Monodensified BDDE | 27G | Deep subcutaneous and/or supraperiosteal | Mostly LMW. [Robust] | Among Vycross, Very Supportive For midface and chin | 33400 | 20.1 | 305.4 | 5.90% | |
| Juvederm VOLUX XC | 25 | Vycross Monophasic Monodensified BDDE | 27G | Subcutaneous and/or supraperiosteal | Mostly LMW. [Very Robust] | Among Vycross, Most lifting For jawline | 665 21 | ||||
| Belotero BALANCE+ | 22.5 | CPM Monophasic Polydensified BDDE | 30G | Mid-to-deep dermis | HMW HA. Integrates into skin easily. Very low Dynamic Strength Score (Pa2). Most “squishable.” 22 | Very forgiving for superficial creases. Does not last long. | 128 21 | ||||
| Revanese VERSA+ | 25 | Thixofix Monophasic BDDE | 27G | Mid-to-deep dermis | Spherical Particles, less hydrophilic HMW HA. | ||||||
| Revanesse LIPS+ | 25 | Thixofix Monophasic BDDE | 30G | Lip mucosa | Spherical Particles, less hydrophilic. HMW HA. | Same product as Versa. Different packaging, smaller needle. | YES | ||||
| RHA REDENSITY (Teoxane) | 15 | Preserved Network Low degree of BDDE | 30G | Superficial-to-mid dermis | HMW HA. | Most stretchable of all the HA products | 4390 | 792 | 133 21 | 1.90% | |
| RHA 2 (Teoxane) | 23 | Preserved Network Low degree of BDDE | 30G | Mid-to-deep dermis May use for radial cheek lines. | HMW HA. | RHA stands for Resilient Hyaluronic Acid | 22000 | 227 | 138.9 | 3.10% | |
| RHA 3 (Teoxane) | 23 | Preserved Network Low degree of BDDE | 27G | Mid-to-deep dermis | HMW HA. | 31900 | 85.3 | 145.8 | 3.60% | ||
| RHA 4 (Teoxane) | 23 | Preserved Network Low degree of BDDE | 27G | Deep dermis and/or superficial subcutaneous | HMW HA. [Most Robust of RHA line] | 81900 | 55 | 263.3 | 4% |
LEGEND
Hyaluronic Acid (HA) A water soluble sugar polymer that belongs to a class of compounds known as glycosaminoglycans. It is made up of long chains of repeating disaccharide units of N-acetylglucosamine and glucuronic acid.18
HA Chain Length ∝ Molecular Weight HA chain length is associated with (proportional to) the molecular weight of the HA chain.18 Short HA Chains = Low Molecular Weight (LMW), Long HA Chains = High Molecular Weight (HMW).
Monophasic Cross-links formed between hyaluronic acid chains make a uniform gel-like structure.
Biphasic Biphasic material consists of 2 or more substances in a blend. In the case of hyaluronic acid, it can exist in two different physical states: cross-linked HA and non-cross-linked HA. Biphasic material is not homogenous (not uniform in character or content).
(%) Degree of Modification (MoD) Degree of Modification (MoD) is the ratio of chemical crosslinkers that form cross-links to the total number of HA disaccharide units.
Dynamic Strength Score (Pa2) The Dynamic Strength Score characterizes the ability of a gel to maintain its physical integrity and gel characteristics over a wide range of stress or deformation values.15
Stretch Score (%/s) Stretch is the ability of the gel to deform (e.g., extend) and adapt to dynamic facial movement. The Stretch Score describes the ability of an HA gel to deform without disruption when subjected to continuous pressure.
G’ (Pa) Elastic modulus or storage module (G’) describes the ability of a gel to rebound to its original shape when a force is applied. High G’ usually correlates with a firmer gel.16
1 Micheels P et al. J Drug Dematol. 2016;15(5):600-606.
14 Data on File. RDRE 2016. Newark, CA: Revance Therapeutics, Inc, 2020.
15 Faivre J et al. Poster presented at: 2020 IMCAS; January, 2020; Paris, France.
16 Fagien S et al. Plast Reconstr Surg. 2019;143:707e-720e.
18 Monslow J et al. Front Immunol. 2015;6:231.
21 Rheologic and Physicochemical Characteristics of HA Fillers: Overview and Relationship to Product Performance, Facial Plast Surg 2022;38:116–123. It is notable that published G’ values differ depending on the study and information source.
22 “Squishable” as an anecdotal observation by Dr. Lum and other injectors when product is injected superficially.
American Society of Plastic Surgeons. 2018 plastic surgery statistics report, published 2019.